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G1424

Globomycin from Streptomyces hagronensis

Name: Globomycin from <I>Streptomyces hagronensis</I>
Brand: SIGMA

Synonym(s):

Globomycin, Glycine, N-(N-(N-(N-(N-(3-hydroxy-2-methyl-1-oxononyl)-N-methylleucyl)-L-alloisoleucyl)-L-seryl)-L-allothreonyl)-, rho-lactone, SF 1902

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About This Item

Empirical Formula (Hill Notation):

C₃₂H₅₇N₅O₉

CAS Number:

67076-74-8

Molecular Weight:

655.82

UNSPSC Code:

51102829

NACRES:

NA.85

MDL number:

MFCD32661892

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Properties

biological source

Streptomyces hagronensis

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

N1(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)OC(C(C1=O)C)CCCCCC)C(O)C)CO)C(CC)C)CC(C)C)C

InChI

1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41)

InChI key

VFGBXFZXJAWPOE-UHFFFAOYSA-N

Description

General description

Globomycin is a cyclic peptide antibiotic, which inhibits the growth of enteric Gram-negative bacteria through cell wall synthesis inhibition.

Application

Globomycin, a new peptide antibiotic with spheroplast-forming activity. I. Taxonomy of producing organisms and fermentation.: This study explores the taxonomy of the producing organisms of Globomycin and details the fermentation processes involved. This antibiotic shows spheroplast-forming activity, indicating its potential application in targeting bacterial cell wall synthesis (Inukai et al., 1978).

Biochem/physiol Actions

Globomycin was found to inhibit LspA, a lipoprotein signal peptidase. It eliminates the maturation of pro-lipoproteins by inhibition of the enzyme that converts pro-lipoprotein to lipoprotein, acting as a substrate analog of the signal sequence in the outer membrane of Gram-negative bacteria.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000496141

0000473151

14190114

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