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M7891

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

BioReagent, for silylations, LiChropur™

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
UNSPSC Code:
12352111
NACRES:
NA.25
PubChem Substance ID:
57654411
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411
Form:
liquid
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vapor density

>1 (vs air)

Quality Level

100

vapor pressure

8.8 mmHg ( 27 °C)

product line

BioReagent

form

liquid

quality

for silylations, LiChropur™

reaction suitability

reaction type: Silylations, reagent type: derivatization reagent

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

solubility

chloroform: soluble 0.1 mg/mL

density

1.07 g/mL at 25 °C (lit.), 1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide(MSTFA) is a BioReagent commonly used for silylation reactions in analyticalchemistry.

Application

N-Methyl-N-(trimethylsilyl)trifluoroacetamide can be used:
  • In the derivatization step of the metabolomics analysis using gas chromatography/mass spectrometry (GC/MS).
  • Derivatization reagent in gas chromatography with flame ionization detection (GC-FID) analysis.

Packaging

Sealed ampules contain 1 ml. Gram sizes are in screw-cap bottles.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

77.0 °F - closed cup

flash_point_c

25 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9281
BCCM7637
BCCL3951
BCCM1869
BCCK4757

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Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
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