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Merck

V4640

VU0357017 monohydrochloride

≥98% (HPLC)

Synonym(s):

4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride, CID 25010775, ML071 hydrochloride, SID 56353039

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About This Item

Empirical Formula (Hill Notation):
C18H27N3O3 · HCl
CAS Number:
1135242-13-5
Molecular Weight:
369.89
NACRES:
NA.77
PubChem Substance ID:
329829053
UNSPSC Code:
12352200
MDL number:
MFCD17215959

Product Name

VU0357017 monohydrochloride, ≥98% (HPLC)

InChI

1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H

SMILES string

Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C

InChI key

XKJQVUIXSBOCPP-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
050M4620V
050M4620

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