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Merck

1361010

USP

Levadopa Related Compound A

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2,5-Dihydroxy-L-tyrosine, 3-(2,4,5-Trihydroxyphenyl)-L-alanine

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About This Item

Empirical Formula (Hill Notation):
C9H11NO5
CAS Number:
27244-64-0
Molecular Weight:
213.19
MDL number:
MFCD22577205
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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Product Name

Levadopa Related Compound A, United States Pharmacopeia (USP) Reference Standard

SMILES string

[N+H3][C@@H](Cc1c(cc(c(c1)O)O)O)C(=O)[O-]

InChI

1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)/t5-/m0/s1

InChI key

YLKRUSPZOTYMAT-YFKPBYRVSA-N

grade

pharmaceutical primary standard

API family

levadopa

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Levadopa Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H315

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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R M Kostrzewa et al.
Amino acids, 19(1), 183-199 (2000-10-12)
To determine if greater amounts of hydroxyl radical (*OH) are formed by dopamine (DA) denervation and treatment with L-dihydroxyphenylalanine (L-DOPA), the neostriatum was DA denervated (99% reduction in DA content) by 6-hydroxydopamine treatment (134microg icv, desipramine pretreatment) of neonatal rats.
J Plastino et al.
FEBS letters, 371(3), 276-278 (1995-09-11)
Limited proteolysis of recombinant Hansenula polymorpha yeast amino oxidase produces a 48 kDa fragment which corresponds to the C-terminal two-thirds of the protein. The fragment contains both TOPA (2,4,5-trihydroxyphenylalanine) and copper, as well as the histidine ligands implicated in copper
H Yamato et al.
Neuroreport, 12(6), 1123-1126 (2001-05-08)
We investigated the effect of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on L-DOPA-derived extracellular dopamine (DA) levels in the striatum of rats with nigrostriatal dopaminergic denervation using in vivo microdialysis. Treatment with fluoxetine (10 mg/kg, i.p.) induced a 41%
G Künig et al.
Journal of neural transmission. Supplementum, 43, 59-62 (1994-01-01)
Neurotoxic substances are discussed to cause neurodegeneration by acting as excitotoxins on glutamate receptors. We investigated the properties of L-beta-oxalyl-amino-alanine (L-BOAA) and 3,4, 6-trihydroxyphenlyalanine (6-OH-Dopa) at the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) glutamate receptor and that of L-BOAA and domoic acid at
Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase.
G W Adams et al.
Methods in enzymology, 258, 90-114 (1995-01-01)
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