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Merck

T3955

TNP

≥95% (HPLC), IP6K inhibitor, powder

Synonym(s):

N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine

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About This Item

Empirical Formula (Hill Notation):
C20H16F3N7O2
CAS Number:
519178-28-0
Molecular Weight:
443.38
UNSPSC Code:
12352200
PubChem Substance ID:
329826781
NACRES:
NA.77
MDL number:
MFCD16875436
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
protect from light

Key Documents

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Product Name

TNP, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: ≥10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

InChI

1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)

InChI key

DDSBPUYZPWNNGH-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Potent and selective IP6K inhibitor; less selective inhibitor of IP3K.
TNP is a potent and selective IP6K inhibitor; less selective inhibitor of IP3K. Discovery of TNP as an inositol trisphosphate (IP3) kinase inhibitor was first reported in 2002, However, a recent reference shows that TNP is more potent as an IP6K inhibitor, making it valuable for study of inositol pyrophosphates.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

TNP is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000449309
0000449308
0000449308
0000449309
0000230818

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L Khorsandi et al.
Bratislavske lekarske listy, 117(11), 659-664 (2017-01-28)
To evaluate the effects of titanium dioxide nanoparticles (TNPs) on morphometric and stereological parameters of mouse testis. TNPs are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. However, the potential toxicity of these nanoparticles is
Marco Thio et al.
PloS one, 7(7), e40986-e40986 (2012-08-23)
Beside the production of complete immunoglobulins IgG, IgE, IgA, IgM and IgD, consisting of tetrameric heterodimers of immunoglobulin heavy and light chains, B cells also secrete immunoglobulin free light chains (Ig-fLC). Previous studies showed that Ig-fLCs are able to induce
Hugh Billings et al.
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Anti-HIV envelope (Env) antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated natural killer cell killing of opsonized infected targets. How these antibodies evolve during HIV infection and treatment remains poorly understood. We describe changes in anti-HIV Env IgG using longitudinal
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PLoS neglected tropical diseases, 7(8), e2395-e2395 (2013-09-07)
Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, we generated a monoclonal antibody (48Eg) against haemoglobin
Jo-Anne E Cavanagh et al.
Toxicology in vitro : an international journal published in association with BIBRA, 48, 342-349 (2018-02-11)
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