M81101
mono-Methyl hydrogen succinate
95%
Synonym(s):
Monomethyl succinate, Succinic acid monomethyl ester
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About This Item
Linear Formula:
CH3OCOCH2CH2COOH
CAS Number:
Molecular Weight:
132.11
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
223-408-2
Beilstein/REAXYS Number:
1722669
MDL number:
Assay:
95%
Form:
powder
InChI key
JDRMYOQETPMYQX-UHFFFAOYSA-N
InChI
1S/C5H8O4/c1-9-5(8)3-2-4(6)7/h2-3H2,1H3,(H,6,7)
SMILES string
COC(=O)CCC(O)=O
assay
95%
form
powder
bp
151 °C/20 mmHg (lit.)
mp
54-57 °C (lit.)
Quality Level
Related Categories
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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L Ladrière et al.
Annals of nutrition & metabolism, 41(2), 118-125 (1997-01-01)
Rats were fasted for 48 h, but infused with either NaCl or the sodium salt of monoethyl succinic acid (EMS), both delivered at a rate of 80 mumol/g body weight per day. The infusion of EMS, as compared to NaCl
S A Hinke et al.
British journal of pharmacology, 150(8), 1031-1043 (2007-03-07)
Two mechanisms have been proposed to explain the insulin-sensitising properties of metformin in peripheral tissues: (a) inhibition of electron transport chain complex I, and (b) activation of the AMP activated protein kinase (AMPK). However the relationship between these mechanisms and
Emma Heart et al.
The Biochemical journal, 403(1), 197-205 (2006-12-22)
The present study was undertaken to determine the main metabolic secretory signals generated by the mitochondrial substrate MeS (methyl succinate) compared with glucose in mouse and rat islets and to understand the differences. Glycolysis and mitochondrial metabolism both have key
K Capito et al.
Journal of molecular endocrinology, 17(2), 101-107 (1996-10-01)
The involvement of phosphatidylcholine (PC) hydrolysis in the regulation of insulin secretion was studied in mouse pancreatic islets prelabelled with [3H]choline. Phospholipase C (PLC) and phospholipase D (PLD) activities were demonstrated and also that of an enzyme that removes both
Y P Zhou et al.
The American journal of physiology, 270(6 Pt 1), E988-E994 (1996-06-01)
Fasting inhibits glucose-induced insulin secretion. We investigated the role of a glucose fatty acid cycle for such inhibition and its molecular basis in pancreatic islets from 48-h fasted rats. The fasting-impaired insulin response to 27 mM glucose was restored by
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