B1436
BAX Inhibiting Peptide V5
≥97% (HPLC), lyophilized powder
Synonym(s):
BIP-V5
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About This Item
Empirical Formula (Hill Notation):
C27H50N6O6S
CAS Number:
Molecular Weight:
586.79
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Quality Level
assay
≥97% (HPLC)
form
lyophilized powder
storage temp.
−20°C
SMILES string
S(CC[C@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)C
InChI
1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1
InChI key
NHMUTADCTDDWPV-YFNVTMOMSA-N
Biochem/physiol Actions
Bax-mediated apoptosis inhibitor; membrane permeable pentapeptide based on the Ku70-Bax inhibiting domain.
BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo
Sawatzky DA, et al.
The American Journal of Pathology, 168(1), 33-41 (2006)