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Merck

P0497

Anti-PMP70 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-70 kDa Peroxisomal membrane Protein, Anti-ABCD3, Anti-PXMP1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01865555

Key Documents

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Product Name

Anti-PMP70 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 70 kDa

species reactivity

human, mouse, rat

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunoprecipitation (IP): 1-2 μg using RIPA extract (0.5 mg) from human HepG2 cells
indirect immunofluorescence: 4-8 μg/mL using mouse NIH3T3 cells
western blot (chemiluminescent): 0.5-1 μg/mL using whole extracts of rat PC12 cells or rat kidney extract or rat liver extract

UniProt accession no.

P28288

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... ABCD3(5825)
mouse ... Abcd3(19299)
rat ... Abcd3(25270)

Related Categories

Application

Anti-PMP70 antibody produced in rabbit has been used in:
  • immunocytochemistry
  • immunostaining
  • immunofluorescence
  • western blotting
  • immunoprecipitation

Biochem/physiol Actions

PMP70 participates in the metabolic transport of long and very long fatty acids into peroxisomes. PMP70 interacts and forms a stable complex with the adrenoleukodystrophy protein(ALDP), and also with several other peroxisomal proteins. ATP binding/hydrolysis by PMP70 and ALDL and their phosphorylation are involved in the regulation of fatty acid transport into peroxisomes. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome, an autosomal recessive disorder and is characterized by defects in import mechanism for peroxisomal matrix enzymes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The 70 kDa peroxisomal membrane protein (PMP70) is a major component of peroxisomal membranes. The peroxisome is a multifunctional single-membrane organelle associated with eukaryotic cells. PMP70 belongs to the ATP binding cassette (ABC) transporter superfamily.

Immunogen

synthetic peptide corresponding to amino acid residues 644-659 of rat PMP70 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in mouse and differs by one amino acid in human.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000507453
0000507453
0000451432
0000451432
0000237211

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein
Nakamura K, et al.
Test, 286(23), 20710-20726 (2011)
Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome
Gartner J, et al.
Nature Genetics, 1(1), 16-16 (1992)
The pestivirus N terminal protease Npro redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by Npro
Jefferson M, et al.
Testing, 9(2), e88838-e88838 (2014)
Jan Van Deun et al.
Journal of extracellular vesicles, 3 (2014-10-16)
Despite an enormous interest in the role of extracellular vesicles, including exosomes, in cancer and their use as biomarkers for diagnosis, prognosis, drug response and recurrence, there is no consensus on dependable isolation protocols. We provide a comparative evaluation of
Matthew Jefferson et al.
PloS one, 9(2), e88838-e88838 (2014-02-20)
The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of interferon production.
View All Related Papers

Related Content

Data Sheet - P0497

Instructions

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