S1141
Spermine tetrahydrochloride
BioReagent, Molecular Biology
Synonym(s):
N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H26N4 · 4HCl
CAS Number:
Molecular Weight:
348.18
UNSPSC Code:
12352116
NACRES:
NA.52
PubChem Substance ID:
EC Number:
206-189-8
Beilstein/REAXYS Number:
3911771
MDL number:
Form:
solid
Quality level:
grade
Molecular Biology
Quality Level
product line
BioReagent
form
solid
mp
310-311 °C (dec.) (lit.)
solubility
H2O: soluble 100 mg/mL, clear, colorless to light yellow
foreign activity
DNase, RNase, protease, NICKase, none detected
storage temp.
room temp
SMILES string
Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
InChI
1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
General description
Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.
Application
Used to precipitate DNA from low salt aqueous buffers.
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Instructions
L L Vindeløv et al.
Cancer research, 40(11), 4295-4300 (1980-11-01)
Flow-cytometric DNA analysis yields information on ploidy and proliferative characteristics of a cell population. The analysis was implemented on small-cell anaplastic carcinoma of the lung using a rapid detergent technique for the preparation of fine-needle aspirates for DNA determination and
Binh V Vu et al.
PloS one, 7(12), e51863-e51863 (2013-01-04)
While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal
D M Hougaard et al.
The Biochemical journal, 238(1), 43-47 (1986-08-15)
Two recently developed fluorescence cytochemical methods, specific for spermidine and spermine, were used to localize polyamines in the endocrine pancreas. The polyamines were restricted to the insulin-producing beta-cells and were mainly associated with the secretory granules. Chemical polyamine determinations carried