SML0370
Kartogenin
≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder
Synonym(s):
2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN
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About This Item
Empirical Formula (Hill Notation):
C20H15NO3
CAS Number:
Molecular Weight:
317.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Kartogenin, ≥98% (HPLC)
SMILES string
O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
InChI
1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChI key
SLUINPGXGFUMLL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >15 mg/mL
storage temp.
room temp
Quality Level
Related Categories
Biochem/physiol Actions
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes.
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Alix Barbe et al.
International journal of molecular sciences, 20(17) (2019-08-31)
Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0.01, 0.1
Yoshitaka Imamichi et al.
The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)
11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. The objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression
Jun Zhao et al.
EBioMedicine, 36, 526-538 (2018-10-09)
Disordered folliculogenesis is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear. Long non-coding RNA (lncRNA) expression in luteinized granulosa cells (hLGCs) derived from women with and without PCOS were analyzed using microarray and
Hanyong Jin et al.
PloS one, 11(7), e0159112-e0159112 (2016-07-16)
Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms of AMH regulation
Dongquan Shi et al.
ACS nano, 10(1), 1292-1299 (2016-01-13)
The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
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