T1892
Thioflavine S
Practical grade, powder
Synonym(s):
Direct Yellow 7
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About This Item
CAS Number:
NACRES:
NA.47
UNSPSC Code:
12171500
EC Number:
215-418-0
MDL number:
Colour Index Number:
49010
Product Name
Thioflavine S, practical grade
grade
practical grade
Quality Level
form
powder
technique(s)
microbe id | staining: suitable
color
light beige to dark beige, to Dark Brown
solubility
ethanol: water (1:1): 1 mg/mL
λmax
360-380
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]
InChI
1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI key
JADVWWSKYZXRGX-UHFFFAOYSA-M
General description
Thioflavine S aids in staining and visualizing β-amyloid plaques in Alzheimer′s disease. Thioflavin S binds to fibrillar β-amyloid plaques, and does not diffuse in the plaques. Thioflavin-S staining aids in visualizing smaller plaques throughout the neocortex, hippocampus and thalamic region.
Application
Thioflavine S has been used to stain and visualize β-amyloid structures in the tissue sections.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity
Yuan P and Grutzendler J
The Journal of Neuroscience, 36(2), 632-641 (2016)
Disha Shah et al.
PloS one, 8(12), e84241-e84241 (2013-12-21)
Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it
MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
Meadowcroft MD, et al.
Journal of Magnetic Resonance Imaging : JMRI, 29(5), 997-1007 (2009)