5.04522
CNS-1102
Synonym(s):
CNS-1102, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride, NMDA Antagonist V
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About This Item
Empirical Formula (Hill Notation):
C20H21N3 · xHCl
CAS Number:
Molecular Weight:
303.40 (free base basis)
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
H2O: 17 mg/mL
storage temp.
2-8°C
InChI
1S/C20H21N3/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19/h4-14H,3H2,1-2H3,(H2,21,22)
InChI key
BFNCJMURTMZBTE-UHFFFAOYSA-N
General description
A non-competitive, subunit non-selective, potent antagonist for NMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14 µM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Target IC50: 0.13, 0.068, 0.087, and 0.14 µM for NR2A –D, respectively.
Physical form
Supplied as a hydrochloride salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Reddy, N., et al. 1994. J. Medicinal Chemistry.37, 260.
Muir, K., et al. 1994. British J. Clinical Pharmacol.38, 33.
Schäbitz, W., et al. 2000. Stroke.31, 1709.
Hoyte, L., et al. 2004. Current Molecular Medicine.4, 131.
Turner, R., et al. 2013. J. of Neurosurgery.1, 14.
Muir, K., et al. 1994. British J. Clinical Pharmacol.38, 33.
Schäbitz, W., et al. 2000. Stroke.31, 1709.
Hoyte, L., et al. 2004. Current Molecular Medicine.4, 131.
Turner, R., et al. 2013. J. of Neurosurgery.1, 14.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Central nervous system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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