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5.04535

QNZ46

Name: QNZ46
Brand: MM

Synonym(s):

QNZ46, NMDA Antagonist VIII, 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₇N₃O₆

CAS Number:

1237744-13-6

Molecular Weight:

443.41

UNSPSC Code:

12352200

MDL number:

MFCD22666391

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 5 mg/mL

storage temp.

2-8°C

InChI

1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+

InChI key

GNLVJIICVWDSNI-LFYBBSHMSA-N

Description

General description

A noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC₅₀ = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.

Biochem/physiol Actions

Primary Target
NMDA receptors

Target IC₅₀: 6, 3, 229, and >300 →M for NR2C, NR2D, NR2A, and NR2B, respectively.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Slight warming is required for complete solubilization.

Other Notes

Mayer, M., et al. 2013. Annu. Rev. Physiol.75, 1.

Hansen, K., 2011. J. Neurosci.9, 3650.

Mosley, C., et al. 2010. J. Med. Chem.53, 5476.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c