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Merck

ESR2

estrogen receptor 2 (ER beta)

Synonymes:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Espèce(s):
Human ESR2 (2100), Mouse Esr2 (13983), Rat Esr2 (25149), dog ESR2 (403639), chicken ESR2 (395575), domestic guinea pig Esr2 (100731304), Domestic Rabbit ESR2 (100346748), domestic cat ESR2 (101086317), Horse ESR2 (100033964), cow ESR2 (281146) ...Plus
ID UniProtKB:
Q92731, A8K8K5, O60608, O60685, O60702, O60703, O75583, O75584
ID du gène:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

Numéro du produit
Description
Espèce(s)
N0632
β-Nicotinamide-adénine-dinucléotide sodium salt, ,
Espèce(s)
human
N7004
β-Nicotinamide-adénine-dinucléotide hydrate, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Espèce(s)
human
43410
β-Nicotinamide-adénine-dinucléotide hydrate, ≥95% (HPLC),
Espèce(s)
human
N1511
β-Nicotinamide-adénine-dinucléotide hydrate, ≥99%,
Espèce(s)
human
N3014
β-Nicotinamide-adénine-dinucléotide hydrate, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Espèce(s)
human

Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
PZ0183
ERB-041, ≥98% (HPLC),
Espèce(s)
human
E7887
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Espèce(s)
human
E9750
Estrone, ≥99%,
Espèce(s)
human, mouse, rat

Small Molecule - Allosteric Modulator

Numéro du produit
Description
Espèce(s)
R1402
Raloxifene hydrochloride, solid,
Espèce(s)
human
PHR1852
Raloxifene Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
1598201
Raloxifene hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Y0001134
Raloxifene hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Y0001135
Raloxifene hydrochloride for peak identification, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
I4409
Fulvestrant, >98% (HPLC),
Espèce(s)
human
Y0001399
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
M6383
2-Methoxyestradiol, ≥98% (HPLC), endothelial cell proliferation inhibitor, powder,
Espèce(s)
human
1286650
Fulvestrant, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Y0001413
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
SAB4500814
Anti-Estrogen Receptor-β antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
05-824
Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal, clone 68-4, Upstate®, from rabbit,
Espèces réactives
human
Application
immunoprecipitation (IP)
western blot
MABE290
Anti-Estrogen Receptor β Antibody, clone 9.88, clone 9.88, from mouse,
Espèces réactives
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
SAB2702145
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Espèces réactives
human, monkey, mouse
Application
ChIP
dot blot
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
HPA068406
Anti-Esr2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
western blot

Cell Lines

Numéro du produit
Description
Espèce(s)
CLLS1075
MCF10A CELLS ESR2 (-/-), ,
Espèce(s)
human

Small Molecule - Mixed Agonist/Antagonist

Numéro du produit
Description
Espèce(s)
E8750
α-Estradiol, powder, ≥98% (TLC),
Espèce(s)
human, rat
E1024
β-Estradiol, meets USP testing specifications,
Espèce(s)
human, mouse, rat
E2758
β-Estradiol, BioReagent, powder, suitable for cell culture,
Espèce(s)
human, mouse, rat
E8875
β-Estradiol, ≥98%,
Espèce(s)
human, mouse, rat
E2257
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Espèce(s)
human, mouse, rat

esiRNA

Numéro du produit
Description
Espèce(s)
EHU900081
MISSION® esiRNA, targeting human ESR2,
Espèce(s)
human