850993
2-Aminoisobutyic acid
98%, for peptide synthesis
Synonyme(s) :
α-Aminoisobutyric acid, 2-Methylalanine, Aib
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A propos de cet article
Formule linéaire :
(CH3)2C(NH2)COOH
Numéro CAS:
Poids moléculaire :
103.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
200-544-0
MDL number:
Beilstein/REAXYS Number:
506496
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2-Aminoisobutyic acid, 98%
Quality Level
assay
98%
form
solid
reaction suitability
reaction type: solution phase peptide synthesis
mp
≥300 °C
application(s)
peptide synthesis
SMILES string
CC(C)(N)C(O)=O
InChI
1S/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7)
InChI key
FUOOLUPWFVMBKG-UHFFFAOYSA-N
General description
2-Aminoisobutyric acid also known as α-aminobutyric acid, is an amino acid used in solution-phase peptide synthesis. It is a desirable building block for peptides because of its strong tendency to cause the peptide to form a helical shape.
Application
2-Aminoisobutyric acid can be used to synthesize self-assembled polypeptide nanoparticles. Incorporation of this compound into the peptide chain can prevent undesired reactions since it is di-α-substituted, and inert to C−H abstraction.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Photochemical methods for peptide macrocyclisation
Chemistry?A European Journal , 27, 69-88 (2021)
C Lucarelli et al.
Journal of chromatography, 541(1-2), 285-296 (1991-03-22)
A procedure is described for the determination of alpha-methyldopa (MD) [L-3-(3,4-dihydroxyphenyl)-2-methylalanine], its metabolite and catecholamines in the urine and plasma of patients undergoing MD therapy, by high-performance liquid chromatography with dual working electrode coulometric detection. An efficient sample preparation procedure
Amphiphilic polypeptides with prolonged enzymatic stability for the preparation of self-assembled nanobiomaterials
Royal Society of Chemistry Advances, 8, 34603-34613 (2018)