AB2148P

Anti-Tumor Necrosis Factor-α Antibody

Name: Anti-Tumor Necrosis Factor-α Antibody
Brand: MM

Chemicon^®, from rabbit

Synonyme(s) :

TNF-alpha

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Nom du produit

Anti-Tumor Necrosis Factor-α Antibody, Chemicon^®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse

manufacturer/tradename

Chemicon^®

technique(s)

ELISA: suitable
neutralization: suitable
western blot: suitable

NCBI accession no.

NP_038721

UniProt accession no.

P06804

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TNF(7124)

Application

Detect Tumor Necrosis Factor-α using this Anti-Tumor Necrosis Factor-α Antibody validated for use in ELISA, NEUT & WB.

ELISA: A concentration of at least 0.5μg/mL (100μL/well) of AB2148P is required to detect 0.2-0.4 ng/well of recombinant mTNF-alpha.

Western Blot: A concentration of 0.1-0.2 μg/mL of AB2148P is required to detect 1.5-3.0 ng/lane of mTNF-alpha, under either reducing or non-reducing conditions.

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of mTNF-a (0.50 ng/ml), a concentration of 0.010-0.015 μg/ml of AB2148P is required.

Optimal working dilutions must be determined by the end user

Biochem/physiol Actions

Reacts with Mouse Tumor Necrosis Factor-alpha (TNF-alpha), a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells.

Immunogen

Highly pure (>98%) recombinant Mouse TNF-alpha.

Other Notes

Replaces: AB1450P

Physical form

Immunoglobulin purified by affinity chromatography employing immobilized mTNF-alpha matrix. A sterile filtered antibody solution (1mg/mL) was lyophilized from 0.5X PBS, pH 7.2. Reconstitute with sterile distilled water.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe de stockage

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Fish oil attenuated dystrophic muscle markers of inflammation via FFA1 and FFA4 in the mdx mouse model of DMD.

Marcos Maciel Junior et al.

Anatomical record (Hoboken, N.J. : 2007), 304(6), 1305-1312 (2020-11-03)

In the present study we investigated the involvement of free fatty acid (FFA) receptors in the anti-inflammatory role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in dystrophic muscles, by administering FFA blockers in the mdx mouse model of dystrophy.

Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair.

Zineb Bouredji et al.

Molecular therapy. Methods & clinical development, 21, 559-573 (2021-05-18)

Although receptor-activator of nuclear factor κB (RANK), its ligand RANKL, and osteoprotegerin (OPG), which are members of the tumor necrosis factor (TNF) superfamily, were first discovered in bone cells, they are also expressed in other cells, including skeletal muscle. We

Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone.

Ting-Yun Chuang et al.

Oncotarget, 8(30), 49735-49748 (2017-05-26)

The innate immune response is a central process that is activated during pathogenic infection in order to maintain physiological homeostasis. It is well known that dexamethasone (Dex), a synthetic glucocorticoid, is a potent immunosuppressant that inhibits the cytokine production induced

Morphine and HIV-1 gp120 cooperatively promote pathogenesis in the spinal pain neural circuit.

Yuqiang Shi et al.

Molecular pain, 15, 1744806919868380-1744806919868380 (2019-08-02)

Monascin and Ankaflavin of Monascus purpureus Prevent Alcoholic Liver Disease through Regulating AMPK-Mediated Lipid Metabolism and Enhancing Both Anti-Inflammatory and Anti-Oxidative Systems.

Jhao-Ru Lai et al.

Molecules (Basel, Switzerland), 26(20) (2021-10-24)

Alcohol metabolism causes an excessive accumulation of liver lipids and inflammation, resulting in liver damage. The yellow pigments monascin (MS) and ankaflavin (AK) of Monascus purpureus-fermented rice were proven to regulate ethanol-induced damage in HepG2 cells, but the complete anti-inflammatory

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Numéro d'article de commerce international

Référence	GTIN
AB2148P	04053252405754

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