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Merck

MAB2624

Anti-Endomucin Antibody, clone V.5C7

clone V.5C7, from rat

Synonyme(s) :

Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14, Endomucin-1/2

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
V.5C7, monoclonal
Application:
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
mouse
Citations:
18
Technique(s):
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
Q9R0H2

Principaux documents

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Nom du produit

Anti-Endomucin Antibody, clone V.5C7, clone V.5C7, from rat

biological source

rat

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

V.5C7, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001156994

UniProt accession no.

Q9R0H2

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Emcn(59308)

Catégories apparentées

Analysis Note

Control
bEND3 cell lysate
Evaluated by Western Blot on mouse endothelioma cell line, bEND3, cell lysate.

Western Blot Analysis: 0.0025 µg/mL of this antibody detected Endomucin in 10 µg of bEND3 cell lysate.

Application

Anti-Endomucin Antibody, clone V.5C7 detects level of Endomucin & has been published & validated for use in WB, IP, IH, FC.
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP of bEND cell lysate (Morgan, 1999).

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in immunhistochemical staining of frozen and paraffin-embedded tissue sections of mouse tongue, heart, uterus, brain, and small intestine (Morgan, 1999).

Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC of transfected COS-7 cells (Morgan, 1999).
Research Sub Category
Organelle & Cell Markers

Adhesion (CAMs)

General description

Endomucin is an endothelial sialomucin belonging to a class of glycoproteins characterized by their high levels of O-glycosolation and rich quantities of sialic acid. It inhibits focal adhesion assembly and hinders extracellular matrix and cell interaction. Observed expression is highest in kidney heart, brain, liver, lung, spleen, and thymus. Endomucin is only found in endothelial cells.
~ 75kDa observed

Immunogen

Mouse endothelial cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Kate Crawford et al.
Cancer biology & therapy, 22(10-12), 619-629 (2021-12-10)
Standard chemotherapy regimens for gastric adenocarcinoma (GAC) have limited efficacy and considerable toxicity profiles. Nab-paclitaxel has shown promising antitumor benefits in previous GAC preclinical studies. Dovitinib inhibits members of the receptor tyrosine kinase family including FGFR, VEGFR and PDGFR, and
Enhancing gastric cancer conventional chemotherapy effects by triple angiokinase inhibitor nintedanib in preclinical models.
Awasthi, et al.
Frontiers in Oncology, 13, 1145999-1145999 (2023)
Meghan Grojean et al.
Journal of cellular and molecular medicine, 25(11), 4950-4961 (2021-05-04)
Elevated expression of multiple growth factors and receptors including c-Met and VEGFR has been reported in gastric adenocarcinoma (GAC) and thus provides a potentially useful therapeutic target. The therapeutic efficacy of foretinib, a c-Met/VEGFR2 inhibitor, was determined in combination with
Kristina Y Aguilera et al.
Bio-protocol, 4(19) (2014-10-05)
Therapy-induced hypoxia drives changes in the tumor microenvironment that contribute to the poor response to therapy. Hypoxia is capable of driving the expression and/or activation of specific signaling cascades (e.g., c-Met, Axl, CTGF), the recruitment of tumor promoting immune cells
Nelida Olave et al.
American journal of physiology. Lung cellular and molecular physiology, 315(4), L535-L544 (2018-06-29)
Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment of lung development in newborn animals and is increased in the lungs of human infants with bronchopulmonary dysplasia (BPD). COX-2 catalyzes the production of cytoprotective prostaglandins, such as prostacyclin (PGI2), as well as proinflammatory mediators
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Numéro d'article de commerce international

RéférenceGTIN
MAB262404053252552397

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