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Merck

PHR1207

2-Butanone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

MEK, Méthyl éthyl cétone, Méthyléthylcétone

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A propos de cet article

Formule linéaire :
C2H5COCH3
Numéro CAS:
78-93-3
Poids moléculaire :
72.11
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823214
EC Number:
201-159-0
Beilstein/REAXYS Number:
741880
MDL number:
MFCD00011648

Principaux documents

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Nom du produit

2-Butanone, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

ZWEHNKRNPOVVGH-UHFFFAOYSA-N

InChI

1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3

SMILES string

CC(CC)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1430101

vapor density

2.49 (vs air)

vapor pressure

71 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

960 °F

expl. lim.

10.1 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.379 (lit.)

bp

80 °C (lit.)

mp

−87 °C (lit.)

density

0.805 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 2-Butanone (Methyl ethyl ketone, MEK), an aliphatic ketone, is considered as an aprotic and protophilic solvent. Its ability as an anticonvulsive agent in lithium-pilocarpine-induced status epilepticus in rats is reported.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0146 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Classe de stockage

3 - Flammable liquids

wgk

WGK 1

flash_point_f

30.2 °F - closed cup

flash_point_c

-1 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition (2012)
Yang Cao et al.
British journal of haematology, 168(5), 701-707 (2014-11-06)
CXCR4(WHIM) frameshift and nonsense mutations follow MYD88(L265P) as the most common somatic variants in Waldenström Macroglobulinaemia (WM), and impact clinical presentation and ibrutinib response. While the nonsense (CXCR4(S338X) ) mutation has been investigated, little is known about CXCR4 frameshift (CXCR4(FS)
Federico Mele et al.
Nature communications, 6, 6431-6431 (2015-03-17)
T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced
Inna V Fedorenko et al.
Proteomics, 15(2-3), 327-339 (2014-10-24)
Basal and kinase inhibitor driven adaptive signaling has been examined in a panel of melanoma cell lines using phosphoproteomics in conjunction with pathway analysis. A considerable divergence in the spectrum of tyrosine-phosphorylated peptides was noted at the cell line level.
Brinda Alagesan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 396-404 (2014-10-29)
Improved therapeutic approaches are needed for the treatment of pancreatic ductal adenocarcinoma (PDAC). As dual MEK and PI3K inhibition is presently being used in clinical trials for patients with PDAC, we sought to test the efficacy of combined targeting of
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