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Merck

34998

Acétonitrile

≥99.9%, HPLC Plus, suitable for IR spectroscopy, HPLC

Synonyme(s) :

Cyanure de méthyle, ACN, Cyanométhane, Éthylnitrile

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About This Item

Formule linéaire :
CH3CN
Numéro CAS:
Poids moléculaire :
41.05
NACRES:
NA.03
PubChem Substance ID:
eCl@ss:
39031501
UNSPSC Code:
41116105
EC Number:
200-835-2
MDL number:
Beilstein/REAXYS Number:
741857
grade:
HPLC Plus
assay:
≥99.9%
technique(s):
HPLC: suitable
IR spectroscopy: suitable
application(s):
food and beverages
bp:
81-82 °C (lit.)
vapor pressure:
72.8 mmHg ( 20 °C)

Nom du produit

Acétonitrile, HPLC Plus, ≥99.9%

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

InChI

1S/C2H3N/c1-2-3/h1H3

SMILES string

CC#N

grade

HPLC Plus

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

baseline drift measuring range

≤12 mAU (210 nm)

technique(s)

HPLC: suitable
IR spectroscopy: suitable

impurities

≤0.0001% free alkali (as NH3)
≤0.0002% non-volatile matter
≤0.001% free acid (as CH3COOH)
≤0.01% water (Karl Fischer)
≤0.5 ppb fluorescence (quinine) at 254 nm
≤0.5 ppb fluorescence (quinine) at 365 nm

halogenated residue

10 ng/L (as heptachlor epoxide)

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

HPLC-gradient

≤0.2 mAU at 254 nm
≤1 mAU at 210 nm

λ

H2O reference

UV absorption

λ: 195 nm Amax: ≤0.10
λ: 200 nm Amax: ≤0.02
λ: 228 nm Amax: ≤0.005
λ: 235 nm Amax: ≤0.0044
λ: 250 nm Amax: ≤0.0044
λ: 400 nm Amax: ≤0.0044

application(s)

food and beverages

format

neat

Quality Level

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Application

L'acétonitrile est utilisé comme constituant d'un système de gradient d'HPLC pour la détection du diisocyanate de diphénylméthane, un produit de dégradation polymère.
Le nouvel acétonitrile de qualité UPLC Plus convient à toutes les applications, notamment :
Spectrométrie de masse, HPLC, CCM, GPC, UV, IR, GC, analyse des résidus de pesticides, synthèse et purification d'ARN/ADN.

General description

L'acétonitrile (MeCN) est un solvant couramment utilisé dans diverses études et possède une constante diélectrique élevée (de 37,5). De nombreux chercheurs ont proposé des procédures de purification permettant d'obtenir différentes qualités d'acétonitrile pour diverses études (polarographie, spectroscopie, etc.).

Other Notes

Information importante
  • L'article réf. 34998-4X2.5L va être supprimé. Nous vous invitons à le commander au flacon sous la référence 34998-2.5L (article physiquement identique et soumis exactement aux mêmes spécifications).
  • L'article réf. 34998-6X1L va être supprimé. Nous vous invitons à le commander au flacon sous la référence 34998-1L (article physiquement identique et soumis exactement aux mêmes spécifications).
Découvrez LiChropur, la gamme de réactifs idéale pour vos analyses par HPLC ou LC-MS
Les récipients Pure-Pac® II requièrent l'utilisation de coupleurs de vanne Macro de Micro Matic pour la distribution des solvants, Z560723.

Packaging

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Preparation Note

Produit filtré sur un filtre de 0,2 μm

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Classe de stockage

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup


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Lot/Batch Number

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    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. Who do I contact about larger solvent volume needs?

    Email us at labessentials@sial.com or visit Sigma-Aldrich Fine Chemicals for development and manufacturing-scale inquiries: safcglobal@sial.com

  4. How do I know what packaging options are available for a solvent?

    The Solvent Center gives you the ability to review all the specifications associated with our solvent packaging. This includes physical dimensions, closure types, dispensing methods, UN/DOT Rating as well as solvent compatibility. Visit the Solvent Center.

  5. Who do I contact if I need a solvent blend, which you do not carry?

    Email us at labessentials@sial.com. For a complete listing of all our Solvent blends, Visit the Solvent Center

  6. The dispensing of solvents provides some challenges due to the number of container options available. What dispensing options are available for each container?

    The Sigma-Aldrich Solvent Center provides numerous dispensing options for each container type. For a complete listing of all our dispensing options, Visit the Solvent Center.

  7. Which solvent grade should I be using for my application?

    Sigma-Aldrich Solvent Applications Table gives a guideline to common applications and the appropriate solvent grades.  Visit: Solvents

  8. What are the options for drying solvents? 

    Sigma-Aldrich offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and Biotech applications.  Sigma-Aldrich also carries various drying agents such as molecular sieves, which are typically compatible with organic solvents.

  9. What apparatus do you recommend for HPLC solvent filtration?

    The Sigma-Aldrich Vacuum Filtration Assembly gives you all the components you need including: funnel top, fritted glass funnel support, filtration flask, aluminum clamp, and silicone stopper.  The Acrodisc Syringe Filters offer high quality filtration for analytical samples, certified for HPLC to ensure low extractable and available in a broad range of membranes to meet sample compatibility requirements.

  10. Can you recommend a Solvent Extractor for organics from aqueous solution?

    Solvent extractors are often used for the quantitative extraction of organics from aqueous solutions and separations in immunoassays. The MIXXOR system has been applied successfully in many laboratory solvent extraction operations and is ideal for the rapid screening of alternative solvents for specific extraction problems.

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Purification of acetonitrile.
Walter M and Ramaley L.
Analytical Chemistry, 45(1), 165-166 (1973)
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is
Hélène Hall et al.
Brain : a journal of neurology, 137(Pt 9), 2493-2508 (2014-07-27)
The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic

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