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Merck

494496

NMP

biotech. grade, ≥99.7%

Synonyme(s) :

1-méthyl-2-pyrrolidone, N-méthyl-2-pyrrolidone, M-PYROL, NMP

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A propos de cet article

Formule empirique (notation de Hill) :
C5H9NO
Numéro CAS:
Poids moléculaire :
99.13
NACRES:
NA.07
PubChem Substance ID:
UNSPSC Code:
12352005
EC Number:
212-828-1
MDL number:
Beilstein/REAXYS Number:
106420
Assay:
≥99.7%
Grade:
biotech. grade
Bp:
202 °C (lit.), 81-82 °C/10 mmHg (lit.)
Vapor pressure:
0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)
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Nom du produit

1-Méthyl-2-pyrrolidinone, biotech. grade, ≥99.7%

grade

biotech. grade

Quality Segment

vapor density

3.4 (vs air)

vapor pressure

0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)

assay

≥99.7%

autoignition temp.

518 °F

expl. lim.

9.5 %

impurities

≤0.005% water, ≤0.01% free amines (CH3NH2)

color

APHA: ≤20

refractive index

n20/D 1.47 (lit.)

pH

7.7-10.0 (20 °C, 100 g/L)

bp

202 °C (lit.), 81-82 °C/10 mmHg (lit.)

mp

−24 °C (lit.)

solubility

acetone: miscible(lit.), alcohol: miscible(lit.), chloroform: miscible(lit.), ethyl acetate: miscible(lit.), water: miscible(lit.)

density

1.028 g/mL at 25 °C (lit.)

λ

H2O reference

UV absorption

λ: 285 nm Amax: 1.00, λ: 300 nm Amax: 0.50, λ: 325 nm Amax: 0.10, λ: 350-400 nm Amax: 0.01

application(s)

peptide synthesis

SMILES string

CN1CCCC1=O

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

General description

Our biotech solvents offer exceptional quality for reliable RNA extraction, ensuring optimal laboratory performance. With low water content and minimal residue, give clean UV spectra to minimize contamination.
  • High-Quality Biotech Solvents: Designed for optimal laboratory performance with low water content and minimal residues.
  • Ideal for RNA Extraction: Essential for genetic testing and research applications like PCR.
  • Ensures Integrity of Genetic Material: Promotes reliable and reproducible results.
  • Industry Compliant: Suitable for both academic and commercial laboratories, enhancing research efficiency.

N-Methyl-2-pyrrolidinone (N-methylpyrrolidone, NMP) is a polar cyclic organic solvent. A study on the impact of NMP on Saccharomyces cerevisiae revealed that it induced aneuploidy. Characteristic properties of NMP include low viscosity, excellent dissolving power and enhanced demulsifying property. It is a better alternative to phenol in selectively treating lube feedstock. The behavior of fullerene-C60 in NMP solution has been examined based on electronic absorption and photoluminescence spectral data. A solution of sodium borohydride (NaBH4) in NMP showed increased reactivity towards debromination of alkyl bromide. The enhanced selectivity of NMP-ethylene glycol solvent mixture for aromatic hydrocarbon extraction has been analyzed by gas chromatography.


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup



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Aggregation of fullerene C60 in N-methylpyrrolidone.
Yevlampieva NP, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 209(2), 167-171 (2002)
Evaluation of extraction properties of N-methylpyrrolidone and ethylene glycol mixtures by gas chromatography.
Wardencki W and Tameesh AHH.
Journal of Chemical Technology and Biotechnology, 31(1), 86-92 (1981)
NaBH4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction.
Torisawa Y, et al.
Bioorganic & Medicinal Chemistry Letters, 11(20), 2787-2789 (2001)