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C0253

Chlorambucil

Name: Chlorambucil
Brand: SIGMA

DNA alkylating agent, powder

Synonyme(s) :

4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₄H₁₉Cl₂NO₂

Numéro CAS:

305-03-3

Poids moléculaire :

304.21

NACRES:

NA.77

PubChem Substance ID:

24278287

UNSPSC Code:

12352200

EC Number:

206-162-0

MDL number:

MFCD00021783

Beilstein/REAXYS Number:

999011

Form:

powder

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Propriétés

Nom du produit

Chlorambucil,

form

powder

Quality Segment

200

storage temp.

2-8°C

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

Gene Information

human ... CYP2D6(1565)

Description

Application

Chlorambucil has been used:

as an alkylating/chemotherapeutic agent to study its anti-inflammatory effects on amyloidogenesis in mice
as a positive control to determine the cytotoxicity in murine leukemic monocyte macrophages
as an adenine-specific DNA-alkylating reagent in the construction of multifunctional conjugate (8950A-Chb(Cl/OH) for mutation-specific DNA alkylation in HeLa S3 cells

Biochem/physiol Actions

Chlorambucil is a nitrogen mustard alkylating agent that acts as an anti-cancer drug. Chlorambucil binds to membranes, RNA, DNA, and proteins. It exhibits anti-inflammatory and anti-tumor activity by DNA cross-linking. Chlorambucil shows therapeutic effects against chronic lymphocytic leukemia (CLL) via a p53-dependent mechanism.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H315,H319,H335,H350

pcodes

P201 - P202 - P261 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c