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Merck

D8893

Dexaméthasone

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Synonyme(s) :

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-méthylpregna-1,4-diène-3,20-dione, 9α-Fluoro-16α-méthyl-11β,17α,21-trihydroxy-1,4-pregnadiène-3,20-dione, 9α-Fluoro-16α-méthylprednisolone, Prednisolone F

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A propos de cet article

Formule empirique (notation de Hill) :
C22H29FO5
Numéro CAS:
50-02-2
Poids moléculaire :
392.46
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
24894235
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
MFCD00064136
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥80% (HPLC)

Principaux documents

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Nom du produit

Dexaméthasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

biological source

synthetic (organic)

sterility

γ-irradiated

product line

BioXtra

assay

≥80% (HPLC)

form

powder

potency

4-500 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

262-264 °C (lit.)

solubility

ethanol: 1 mL/vial, clear

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

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Catégories apparentées

Biochem/physiol Actions

Agent anti-inflammatoire du type glucocorticoïde
Agent anti-inflammatoire du type glucocorticoïde. Régule la survie, la croissance et la différenciation des lymphocytes T. Inhibe l′induction de l′oxyde nitrique synthase.
Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV). Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins. It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.

Application

Dexamethasone has been used as a component of osteogenic differentiation medium. It has also been used to study apoptosis, cell signaling pathways and gene expression.

Physical form

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000456809
0000456809
0000450272
0000450272
0000429115

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the best way to dissolve Product D8893, Dexamethasone?

    The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).

  6. What is the solubility of Product D8893, Dexamethasone, in ethanol?

    The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.

  7. What is the solubility of Product D8893, Dexamethasone, in DMSO?

    The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.

  8. What solution stability information do you have available for Product D8893, Dexamethasone?

    We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.

  9. How do the dexamethasone products D8893 and the D4902 compare?

    They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Fresh-frozen biological allograft remains the most effective substitute for the 'gold standard' autograft, sharing many of its osteogenic properties but, conversely, lacking viable osteogenic cells. Tissue engineering offers the opportunity to improve the osseointegration of this material through the addition
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