G8790

Glycine

Name: Glycine
Brand: SIGMA

≥98.5%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

Synonyme(s) :

Acide aminoacétique, Acide aminoéthanoïque, Glycocolle

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About This Item

Formule linéaire :

NH₂CH₂COOH

Numéro CAS:

56-40-6

Poids moléculaire :

75.07

NACRES:

NA.26

PubChem Substance ID:

24895353

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

Nom du produit

Glycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

biological source

non-animal source

agency

meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

assay

≥98.5%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

pH

5.9-6.4

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

H₂O: 100 mg/mL

Quality Level

300

Gene Information

rat ... Grin2a(24409)

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Catégories apparentées

Acides aminés

Chimie et produits biochimiques

Produits biochimiques

Suppléments et réactifs pour la culture cellulaire

Biochem/physiol Actions

Neurotransmetteur inhibiteur de la moelle épinière, régulateur allostérique des récepteurs du NMDA.

Application

Amino acid for use in cell culture media development applications and existing media formulations.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes.

Alexander Carvajal-González et al.

Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)

The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus.

Richard A Felix et al.

Brain structure & function, 220(5), 2639-2652 (2014-06-30)

The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route

Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.

Zoé Husson et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)

The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory

Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin.

Bethany L Johnson-Kerner et al.

Human molecular genetics, 24(5), 1420-1431 (2014-11-16)

Giant axonal neuropathy (GAN) is a progressive neurodegenerative disease caused by autosomal recessive mutations in the GAN gene resulting in a loss of a ubiquitously expressed protein, gigaxonin. Gene replacement therapy is a promising strategy for treatment of the disease;

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.

Dmitrij A Lisak et al.

Biochimica et biophysica acta, 1853(9), 2104-2114 (2015-03-15)

Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca²⁺ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6.

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Contenu apparenté

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