M1523
Muscimol
≥98% (TLC), powder, GABAA receptor agonist.
Synonyme(s) :
3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
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A propos de cet article
Formule empirique (notation de Hill) :
C4H6N2O2
Numéro CAS:
Poids moléculaire :
114.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
220-430-4
MDL number:
Beilstein/REAXYS Number:
1618960
Form:
powder
Quality level:
Service technique
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Laissez-nous vous aiderNom du produit
Muscimol, powder
form
powder
Quality Level
color
white to off-white
storage temp.
2-8°C
SMILES string
NCC1=CC(=O)NO1
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
Gene Information
rat ... Gabra2(29706)
General description
Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.
Application
Muscimol has been used:
- to reduce conditioned fear-expression in lateral amygdala (LA)
- to eliminate cortical cell response in ferrets
- to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches
Biochem/physiol Actions
GABAA receptor agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - STOT SE 3
target_organs
Central nervous system
Classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Contenu apparenté
Instructions
Julen Hernandez-Lallement et al.
Current biology : CB, 30(6), 949-961 (2020-03-07)
Empathy, the ability to share another individual's emotional state and/or experience, has been suggested to be a source of prosocial motivation by attributing negative value to actions that harm others. The neural underpinnings and evolution of such harm aversion remain
Su-Hyuk Ko et al.
International journal of molecular sciences, 21(22) (2020-11-19)
Autophagy is a conserved pathway that plays a key role in cell homeostasis in normal settings, as well as abnormal and stress conditions. Autophagy dysfunction is found in various neurodegenerative diseases, although it remains unclear whether autophagy impairment is a
Handbook of Mushroom Poisoning: Diagnosis and Treatment (1994)