M1523
Muscimol
≥98% (TLC), powder, GABAA receptor agonist.
Synonyme(s) :
3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
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A propos de cet article
Formule empirique (notation de Hill) :
C4H6N2O2
Numéro CAS:
Poids moléculaire :
114.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
220-430-4
MDL number:
Beilstein/REAXYS Number:
1618960
Form:
powder
Service technique
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Laissez-nous vous aiderNom du produit
Muscimol, powder
form
powder
Quality Segment
color
white to off-white
storage temp.
2-8°C
SMILES string
NCC1=CC(=O)NO1
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
Gene Information
rat ... Gabra2(29706)
General description
Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.
Application
Muscimol has been used:
- to reduce conditioned fear-expression in lateral amygdala (LA)
- to eliminate cortical cell response in ferrets
- to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches
Biochem/physiol Actions
GABAA receptor agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - STOT SE 3
target_organs
Central nervous system
Classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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