M6546
(±)-2-(p-Methoxyphenoxy)propionic acid
solid, ≥98%
Synonyme(s) :
PMP
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A propos de cet article
Formule empirique (notation de Hill) :
C10H12O4
Numéro CAS:
Poids moléculaire :
196.20
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Laissez-nous vous aiderNom du produit
(±)-2-(p-Methoxyphenoxy)propionic acid, ≥98%
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
solid
SMILES string
COc1ccc(OC(C)C(O)=O)cc1
InChI
1S/C10H12O4/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9/h3-7H,1-2H3,(H,11,12)
InChI key
MIEKOFWWHVOKQX-UHFFFAOYSA-N
Application
(±)-2-(p-Methoxyphenoxy)propionic acid may be used as a sweet taste receptor antagonist to study its effect on allulose-induced glucagon-like peptide 1 (GLP-1) secretion rats. It may also be used to study the response of the secretin tumor cell line (STC-1) to sweetener in the presence and absence of (±)-2-(p-methoxyphenoxy)propionic acid or lactisole.
Biochem/physiol Actions
As a taste modulator, the sodium salt inhibits the perception of sweetness in humans, but not in rats.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Li-Chun Chen et al.
Food chemistry, 212, 768-777 (2016-07-05)
The biological functions of cell membranes strongly influence the binding and transport of molecular species. We developed STC-1 cell line stably expressing the sweet taste receptor (T1R2/T1R3), and explored the possible correlation between sweeteners and membrane dipole potential of STC-1
Xiulian Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(3), 1220-1234 (2017-10-06)
Bleomycin is a clinically used anti-cancer drug that produces DNA breaks once inside of cells. However, bleomycin is a positively charged molecule and cannot get inside of cells by free diffusion. We previously reported that the cell surface negatively charged
Paolo Tommasino et al.
Frontiers in neurorobotics, 11, 65-65 (2017-12-19)
A major challenge in robotics and computational neuroscience is relative to the posture/movement problem in presence of kinematic redundancy. We recently addressed this issue using a principled approach which, in conjunction with nonlinear inverse optimization, allowed capturing postural strategies such
Lilli Saarinen et al.
PloS one, 12(4), e0174898-e0174898 (2017-04-21)
Pseudomyxoma peritonei (PMP) is a subtype of mucinous adenocarcinoma mainly restricted to the peritoneal cavity and most commonly originating from the appendix. The genetic background of PMP is poorly understood and no targeted treatments are currently available for this fatal
Kensuke Ninomiya et al.
The EMBO journal, 39(3), e102729-e102729 (2019-11-30)
A number of long noncoding RNAs (lncRNAs) are induced in response to specific stresses to construct membrane-less nuclear bodies; however, their function remains poorly understood. Here, we report the role of nuclear stress bodies (nSBs) formed on highly repetitive satellite
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