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Merck

M6908

Myeloperoxidase from human leukocytes

lyophilized powder, ≥50 units/mg protein

Synonyme(s) :

MPO, Peroxidase, myelo

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A propos de cet article

Numéro CAS:
9003-99-0
NACRES:
NA.32
UNSPSC Code:
12352200
MDL number:
MFCD00131641
Numéro CE :
1.11.2.2 (BRENDA, IUBMB)

Principaux documents

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Nom du produit

Myeloperoxidase from human leukocytes, lyophilized powder, ≥50 units/mg protein

InChI

1S/H2O3/c1-3-2/h1-2H

SMILES string

[O+H2]O[O-]

InChI key

JSPLKZUTYZBBKA-UHFFFAOYSA-N

biological source

human leucocytes

form

lyophilized powder

specific activity

≥50 units/mg protein

solubility

H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)

UniProt accession no.

P05164

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... MPO(4353)

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Analysis Note

Source material tested and found negative for antibody to HIV and for HBSAG.

Application

Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
  • as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
  • as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
  • as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO

Biochem/physiol Actions

Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).

General description

Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.

Other Notes

Lysosomal heme-containing protein.
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C

Physical form

Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000489335
0000489335
0000507486
0000507486
0000468307

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Consulter la Bibliothèque de documents

The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.
Chang KS
Leukemia, 1(15), 458-462 (1987)
Sharbel Weidner Maluf et al.
Genetics and molecular biology, 43(2), e20180390-e20180390 (2020-06-20)
The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide
Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice.
Bergeron Y
Infection and Immunity, 66(3), 912-922 (1998)
Clinical manifestation of myeloperoxidase deficiency.
Lanza F
Journal of Molecular Medicine, 76(10), 676-681 (1998)
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
Romac JMJ, et al.
Nature Communications, 9(1715), 1-10 (2018)
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