P8761
Probenecid
≥98% (NaOH, titration), powder, uricosuric agent
Synonyme(s) :
p-(Dipropylsulfamoyl)benzoic acid
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A propos de cet article
Formule empirique (notation de Hill) :
C13H19NO4S
Numéro CAS:
Poids moléculaire :
285.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
200-344-3
MDL number:
Assay:
≥98% (NaOH, titration)
Service technique
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Laissez-nous vous aiderNom du produit
Probenecid,
assay
≥98% (NaOH, titration)
Quality Segment
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChI key
DBABZHXKTCFAPX-UHFFFAOYSA-N
Gene Information
human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376)
Application
Useful as an inhibitor of the organic anion transporter, MRP.
Probenecid has been used:
- as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay
- as a component of calcium sensitive dye for calcium mobilization Studies
- as a supplement in Hank′s balanced salt solution (HBSS) assay buffer
Biochem/physiol Actions
Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Mot-clé
Warning
Codes de danger
Mentions de précaution
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Classe de stockage
11 - Combustible Solids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
EPI (équipement de protection individuelle)
dust mask type N95 (US), Eyeshields, Gloves
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