R0395
Rapamycin
from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor
Synonyme(s) :
23,27-Époxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
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A propos de cet article
Nom du produit
Rapamycine from Streptomyces hygroscopicus, ≥95% (HPLC), powder
SMILES string
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
assay
≥95% (HPLC)
form
powder
color
off-white
solubility
ethanol: 2 mM, DMSO: soluble
antibiotic activity spectrum
fungi, yeast
mode of action
enzyme | inhibits, protein synthesis | interferes
storage temp.
−20°C
Quality Level
Gene Information
human ... FKBP1A(2280)
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General description
Application
- pour traiter les cellules BV2 ou BV2-LC3 dans le cadre de l'analyse de l'autophagie
- en tant qu'activateur de l'autophagie dans les cellules souches mésenchymateuses de la moelle osseuse (CSM-MO) transfectées avec un lentivirus porteur d'un petit ARN interférent ciblant FOXO3 (siFOXO3) afin d'étudier les effets de Forkhead Box O3 (FOXO3) sur l'autophagie des CSM-MO
- pour pré-incuber les villosités afin d'inhiber la signalisation de la cible mammalienne du complexe 1 de la rapamycine (mTORC1)
Biochem/physiol Actions
Features and Benefits
Other Notes
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the solubility of Product R0395, Rapamycin?
Rapamycin is soluble in DMSO and in methanol (each at 25 mg/mL) and in ethanol (2 mM). It is insoluble in water. Additional solubility information is in the product information sheet (under Documents, above).
How should we store solutions of Product R0395, Rapamycin?
Rokaw, M.D. et al. J. Biol. Chem. 271, 32468 (1996) described storage of a 2 mM solution of rapamycin in ethanol at -70 °C which was diluted into serum-free media before use. Unless otherwise noted for other solvents, it may be best to prepare solutions fresh and protected from light. Please refer to our product information sheet at our website.
What is the shelf life of Product R0395, Rapamycin, as received?
The product has a recommended retest date of 2 years but the actual recommended retest date for each lot is on the Certificate of Analysis. We guarantee the quality of the product through this date for unopened bottles stored at -20 °C.
What are the extinction coefficient values for Product R0395, Rapamycin, solutions?
The E1% extinction coefficient values in 95% ethanol at 267 nm, 277 nm and 288 nm have been reported and are listed in the product information sheet (under Documents, above).
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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