S0292

Silymarin

Name: Silymarin
Brand: SIGMA

flavonolignans

Synonyme(s) :

flavolignans

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About This Item

Numéro CAS:

65666-07-1

UNSPSC Code:

12352202

NACRES:

NA.81

MDL number:

MFCD01776359

Nom du produit

Silymarin, flavonolignans

SMILES string

O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

InChI key

SEBFKMXJBCUCAI-UHFFFAOYSA-N

biological source

plant (Silybum marianum)

form

powder

technique(s)

toxicology assay: suitable

application(s)

microbiology

storage temp.

−20°C

Quality Level

200

Application

Silymarin has been used to study:

its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
its effect on liver toxication induced by Fumonisin B1 in mice

Biochem/physiol Actions

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.

Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.

Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.

General description

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Other Notes

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice

Sozmen M, et al.

Journal of Veterinary Science, 15(1), 51-60 (2012)

Silymarin suppresses HepG2 hepatocarcinoma cell progression through downregulation of Slit-2/Robo-1 pathway.

Nuriye Ezgi Bektur Aykanat et al.

Pharmacological reports : PR, 72(1), 199-207 (2020-02-06)

14 million people are diagnosed with new cancer and approximately 8 million people die from cancer every year. Hepatocellular carcinoma is the most common type of liver cancer and covers almost 5-6% of cancer deaths worldwide. Silybum marianum, a plant

Multitargeted therapy of cancer by silymarin

Ramasamy K and Agarwal R

Cancer letters, 269(2), 352-362 (2008)

Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model

Eser N, et al.

Phytomedicine, 19(8-9), 840-845 (2012)

Silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model.

Laise Mara Oliveira Miranda et al.

Biomedical and environmental sciences : BES, 33(9), 690-700 (2020-10-28)

To evaluate the efficiency of silymarin (SMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus (T1DM). Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with SMN at doses of

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