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T6515

Cholecystokinin Fragment 30-33 Amide

≥95% (HPLC)

Synonyme(s) :

CCK-4, Gastrin Tetrapeptide, Tetragastrin, Trp-Met-Asp-Phe amide

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A propos de cet article

Formule empirique (notation de Hill) :
C29H36N6O6S
Numéro CAS:
1947-37-1
Poids moléculaire :
596.70
NACRES:
NA.32
PubChem Substance ID:
24900382
UNSPSC Code:
12352202
MDL number:
MFCD00076492
Form:
powder
Assay:
≥95% (HPLC)
Mol wt:
59670 g/mol
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Quality Segment

200

assay

≥95% (HPLC)

form

powder

mol wt

59670 g/mol

technique(s)

toxicology assay: suitable

solubility

DMF: 20 mg/mL, clear, colorless to yellow

suitability

suitable for molecular biology

UniProt accession no.

P06307, P30553

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O

InChI

1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1

InChI key

RGYLYUZOGHTBRF-BIHRQFPBSA-N

Gene Information

human ... CCK(885)
rat ... Cckbr(25706)

General description

Research area: Neuroscience

Several biologically active fragments of the neuropeptide cholecystokinin (CCK) are present in the brain, where they interact with CCK-A and CCK-B receptors. Among these fragments, CCK-4 is notably abundant in the cortical and limbic brain structures. CCK-4, a bioactive form of cholecystokinin, is a peptide hormone that regulates food intake by binding to CCK receptors in the gut and brain.

Application

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.Cholecystokinin Fragment 30-33 Amide has been used to induce anxiolytic- and antidepressant-like effects and study the role of neuropeptide Y, in mice.

Biochem/physiol Actions

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing new anxiolytic drugs.CCK-4 acts selectively through CCK-B receptors and is recognized for its role in regulating emotional behaviors. Studies on CCK knock-down mice have indicated anxiolytic- and antidepressant-like effects.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Cholecystokinin Fragment 30-33 Amide dissolves in Dimethylformamide at 20 mg/ml to yield a clear, colorless to yellow solution.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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