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Merck

1082708

USP

2,6-Di-tert-butyl-4-methylphenol

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Butylhydroxytoluène, Hydroxytoluène butylé

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A propos de cet article

Formule linéaire :
[(CH3)3C]2C6H2(CH3)OH
Numéro CAS:
128-37-0
Poids moléculaire :
220.35
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749182
EC Number:
204-881-4
Beilstein/REAXYS Number:
1911640
MDL number:
MFCD00011644

Principaux documents

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Nom du produit

2,6-Di-tert-butyl-4-methylphenol, United States Pharmacopeia (USP) Reference Standard

manufacturer/tradename

USP

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

grade

pharmaceutical primary standard

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

API family

butylated hydroxytoluene

form

crystalline powder

autoignition temp.

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

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Catégories apparentées

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Butylated hydroxytoluene USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Dutasteride and Tamsulosin Hydrochloride Capsules

General description

Butylated hydroxytoluene (BHT) is a synthetic antioxidant commonly used in biologic formulations to prevent oxidative degradation. It acts as a preservative, protecting biologic products from oxidation, which can affect the potency and stability of sensitive molecules. Its application is critical in maintaining the integrity of biologics, particularly those that are exposed to air or light during production and storage.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Sales restrictions may apply.
This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Butylated Hydroxytoluene
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(6), 5652-5652 (2021)
Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene.
A L Branen
Journal of the American Oil Chemists' Society, 52(2), 59-63 (1975-02-01)
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).
H Witschi et al.
Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)
A M Malkinson
Environmental mutagenesis, 5(3), 353-362 (1983-01-01)
Although the average American's daily consumption of BHT can be measured in milligrams, there are numerous reports that BHT causes organ damage in laboratory animals. Only a few genotoxic effects of BHT have been reported, however, including mutagenicity in the
E M Bomhard et al.
Mutation research, 277(3), 187-200 (1992-09-01)
Butylated hydroxytoluene (BHT) is an effective, widely used, low cost antioxidant. A host of studies examining the potential of BHT to cause point mutations have been published. They include in vitro studies on various bacterial species and strains and on
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