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521000 Phenylarsine Oxide - CAS 637-03-6 - Calbiochem

A membrane-permeable protein tyrosine phosphatase inhibitor (IC₅₀ = 18 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX

Primary Target: Protein tyrosine phosphatase
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      637-03-6C₆H₅AsO
      Description
      OverviewA membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).
      Catalogue Number521000
      Brand Family Calbiochem®
      SynonymsPAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX
      References
      ReferencesTakahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
      Carey, J.O., et al. 1995. Diabetes 44, 1995.
      Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
      Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
      Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.
      Product Information
      CAS number637-03-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₆H₅AsO
      Chemical formulaC₆H₅AsO
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein tyrosine phosphatase
      Primary Target IC<sub>50</sub>18 µM against protein tyrosine phosphatase
      Purity≥96% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCH8100000
      Safety Information
      R PhraseR: 26/27/28-34-40

      Very toxic by inhalation, in contact with skin and if swallowed.
      Causes burns.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 26-27-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Take off immediately all contaminated clothing.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      521000 0

      Documentation

      Phenylarsine Oxide - CAS 637-03-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Phenylarsine Oxide - CAS 637-03-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      521000

      References

      Reference overview
      Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
      Carey, J.O., et al. 1995. Diabetes 44, 1995.
      Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
      Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
      Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Protein Phosphatases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-September-2008 JSW
      SynonymsPAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX
      DescriptionA membrane-permeable phosphotyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56lck protein tyrosine kinase. Blocks TNFα-dependent activation of the NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 µM, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.
      FormWhite solid
      CAS number637-03-6
      RTECSCH8100000
      Chemical formulaC₆H₅AsO
      Structure formulaStructure formula
      Purity≥96% by titration
      SolubilityCHCl₃ (100 mg/ml) or DMSO (50 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 6949
      ReferencesTakahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
      Carey, J.O., et al. 1995. Diabetes 44, 1995.
      Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
      Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
      Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.