114556 - Certificate of Quality - Spectroquant Nitrate Cell Test in seawater / Nitrat-Küvettentest in Seewasser / Test en cubetas Nitratos en agua de mar
- Document Type:
- Certificate
- Product Catalog Number:
- 114556
nitrat
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114773 - Certificate of Quality - Spectroquant Nitrate Test / Nitrat-Test / Test Nitratos
- Document Type:
- Certificate
- Product Catalog Number:
- 114773
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101842 - Certificate of Quality - Spectroquant Nitrate Test / Nitrat-Test / Test Nitratos
- Document Type:
- Certificate
- Product Catalog Number:
- 101842
- Product Catalog Name:
- Nitrate Test
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109713 - Certificate of Quality - Spectroquant Nitrate Test / Nitrat-Test / Test Nitratos
- Document Type:
- Certificate
- Product Catalog Number:
- 109713
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Label 117961 RQeasy Nitrate Test / Nitrat-Test
- Document Type:
- User Guide
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Nitrate in Waste Water
- Document Type:
- Application
- Product Catalog Number:
- Multiple
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A Nitrate Ester of Sedative Alkyl Alcohol Improves Muscle Function and Structure in a Murine Model of Duchenne Muscular Dystrophy.
- Nitric oxide (NO) has major physiological and cellular effects on muscle growth, repair, and function. In most muscle biopsies from humans with myopathies, sarcolemma-localized neuronal nitric oxide synthase (nNOS) is either reduced or not detected, particularly in dystrophin-deficient Duchenne muscular dystrophy (DMD). Abnormal NO signaling at the sarcolemmal level is integrally involved in the pathogenesis and accounts, at least in part, for the muscle weakness of DMD. Dystrophic muscle fibers exhibit an increased susceptibility to contraction-induced membrane damage. Muscle relaxants function to prevent muscle wasting by decreasing nerve impulses and reducing calcium influx that regulates tensing or tightening of muscle fibers. We have recently developed a new class of nitric esters that combines the pharmacological functions of NO and muscle relaxation. Here, we report the synthesis and properties of the nitric ester (MMPN) of 2-methyl-2-n-propyl-1,3-propanediol (MPP) and its effect in mdx dystrophic mice, a murine model of DMD. MMPN produced significant improvements in biochemical, pathological, and functional phenotypes in the mouse model. The endurance of exercise was extended by 47% in time to exhaustion and 84% in running distance. Serum CK level was decreased by 30%. Additionally, MMPN decreased intracellular free calcium concentration without causing skeletal muscle weakness. No hepatic or renal toxicities were observed during the study. Our investigations unveil a potential new treatment for muscular diseases.
- Document Type:
- Reference
- Product Catalog Number:
- AB3239
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Nitrate in Beetroot Juice
- Document Type:
- Application
- Product Catalog Number:
- Multiple
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Nitrate Spectroquant Test Kits Equivalency Checklist for Laboratories 2017
- Document Type:
- Technical Information
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Nitrate in Carrot Juice (Beverages)
- Document Type:
- Application
- Product Catalog Number:
- Multiple