114715
Phenylhydrazine hydrochloride
≥99%
Sinónimos:
Phenylhydrazinium chloride
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Fórmula lineal:
C6H5NHNH2 · HCl
Número CAS:
Peso molecular:
144.60
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-444-7
Beilstein/REAXYS Number:
3594958
MDL number:
Assay:
≥99%
Form:
solid
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥99%
form
solid
mp
250-254 °C (dec.) (lit.)
functional group
hydrazine
SMILES string
Cl[H].NNc1ccccc1
InChI
1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H
InChI key
JOVOSQBPPZZESK-UHFFFAOYSA-N
Application
Phenylhydrazine hydrochloride is used in the examination of tyrosine phosphorylation of Janus protein tyrosine kinase (JAKs) in the EPO-responsive normal erythroblastoid cells of anemic mice.
Biochem/physiol Actions
Phenylhydrazine hydrochloride causes acute hemolysis when injected intraperitoneally in to wild-type and Hp and Hx single-null mice. It suppresses the horseradish peroxide (HRP) residual activity in tissue sections of animals.
Preparation Note
50 gm of Phenylhydrazine hydrochloride dissolves in 1 mL of water to yield a clear, very faint yellow solution.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1
Clase de almacenamiento
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Y Yamamura et al.
Molecular and cellular biology, 18(3), 1172-1180 (1998-03-06)
Abnormal erythropoietin (EPO)-independent cell growth is induced after infection of erythroid progenitor cells with a polycythemic strain of Friend virus (FVp). Binding of its Env-related glycoprotein (gp55) to the EPO receptor (EPOR) mimics the activation of the EPOR with EPO.