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06-272

Anti-JAK1 Antibody

serum, Upstate®

Sinónimos:

Anti-AIIDE, Anti-JAK1B, Anti-JTK3

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
51
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, hamster, mouse, human, rat

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_002227

UniProt accession no.

P23458

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... JAK1(3716)

General description

130 kDa

Immunogen

HPLC-purified (>98%) peptide corresponding to 21 amino acids of human JAK1 (KTLIEKERFYESRCRPVTPS-C)

Application

Anti-JAK1 Antibody detects level of JAK1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
Immunological Signaling

Biochem/physiol Actions

JAK1

Physical form

Antiserum
whole rabbit antiserum containing 0.05% sodium azide

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on RIPA lysate from mouse CTLL lymphocytes, TF-1 erythroleukemic cells or mouse thymus

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

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Contenido relacionado

Pathways and Biomarkers of JAK/STAT Signaling

Pathways and Biomarkers of JAK/STAT Signaling

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
Gonzalez-Garcia, A., et al
The Journal of Biological Chemistry, 272, 10220-10226 (1997)
C F Lai et al.
The Journal of biological chemistry, 274(12), 7793-7802 (1999-03-13)
Interleukin (IL)-6 is a major regulator of hepatic acute-phase plasma protein (APP) genes. The membrane-proximal 133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Tortolani, P J, et al.
Blood, 85, 3444-3451 (1995)
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SKUGTIN
06-27204053252326875