361556
GSK-3 Inhibitor IX, Control, MeBIO
The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Sinónimos:
GSK-3 Inhibitor IX, Control, MeBIO, 1-Methyl-BIO
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Fórmula empírica (notación de Hill):
C17H12BrN3O2
Número CAS:
Peso molecular:
370.20
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark red
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2C
InChI
1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,15,19H,1H3/b16-14-
InChI key
ATNXSIPNXWSMRK-PEZBUJJGSA-N
General description
A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
Biochem/physiol Actions
Product does not compete with ATP.
Reversible: no
Target IC50: >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β
Cell permeable: yes
Primary Target
Relevant kinase inactive control
Relevant kinase inactive control
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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Verónica Uribe-Etxebarria et al.
Cells, 9(3) (2020-03-12)
Dental pulp stem cells (DPSCs) from adult teeth show the expression of a very complete repertoire of stem pluripotency core factors and a high plasticity for cell reprogramming. Canonical Wnt and Notch signaling pathways regulate stemness and the expression of