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K4000

Canamicina sulfate from Streptomyces kanamyceticus

Animal Component-free

Sinónimos:

Canamicina A, Canamicina sulfate salt

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Fórmula empírica (notación de Hill):
C18H36N4O11 · H2O4S
Número CAS:
25389-94-0
Peso molecular:
582.58
NACRES:
NA.76
PubChem Substance ID:
24896236
UNSPSC Code:
51281654
EC Number:
246-933-9
MDL number:
MFCD00070253
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biological source

Streptomyces kanamyceticus

Quality Level

200

form

powder

potency

≥750 μg per mg (dry basis)

color

white to off-white

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

mode of action

protein synthesis | interferes

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

General description

Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.

Application

Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used:
  • in the research of bacterial antibiotic resistance
  • in the research on the effect of different antibiotics on bud regeneration

Biochem/physiol Actions

Modo de acción: El producto actúa uniéndose a la subunidad ribosómica 70S, inhibiendo la translocación y provocando una codificación errónea.

Modo de resistencia: las enzimas modificadoras de los aminoglucósidos (como la acetiltransferasa, la fosfotransferasa y la nucleotidiltransferasa) pueden alterar este antibiótico y evitar su interacción con los ribosomas.

Espectro antimicrobiano: El sulfato de canamicina es eficaz contra las bacterias gramnegativas y grampositivas, y contra los micoplasmas.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Preparation Note

Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000519639
0000519639
0000488866
0000488866
0000494667

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Didrik H Grevskott et al.
Frontiers in microbiology, 8, 24-24 (2017-02-06)
The mechanisms for the development and spread of antibacterial resistance (ABR) in bacteria residing in environmental compartments, including the marine environment, are far from understood. The objective of this study was to examine the ABR rates in Escherichia coli and
Effect of gelling agents and antibiotics on adventitious bud regeneration from In vitro leaves of pear
Chevreau et al.
In Vitro Cellular & Developmental Biology. Plant, 33, 173?179-173?179 (1997)
J Yuyang Lu et al.
Cell reports, 30(10), 3296-3311 (2020-03-12)
Repetitive elements are abundantly distributed in mammalian genomes. Here, we reveal a striking association between repeat subtypes and gene function. SINE, L1, and low-complexity repeats demarcate distinct functional categories of genes and may dictate the time and level of gene
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