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PHR1292

Zidovudine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

3′-Azido-3′-deoxythymidine, AZT, Azidothymidine, ZDV, Zidovudine

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Fórmula empírica (notación de Hill):
C10H13N5O4
Número CAS:
30516-87-1
Peso molecular:
267.24
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823283
MDL number:
MFCD00006536
Beilstein/REAXYS Number:
3595791
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Z1900000, traceable to USP 1724500

API family

zidovudine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

113-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

General description

Zidovudine (AZT) is a thymidine analog anti-HIV drug, known to decrease the mortality rate in patients affected with HIV. The mode of action involves inhibiting the activity of viral reverse transcriptase and interrupting HIV replication.

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

Zidovudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, tablets and drug dosage forms by chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Reverse transcriptase inhibitor active against HIV-1 virus.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0303 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Spectrophotometric determination of Zidovudine in pharmaceuticals based on charge-transfer complexation involving N-bromosuccinimide, metol and sulphanilic acid as reagents
Basavaiah K, et al.
Journal of Chemistry, 4(2), 173-179 (2007)
Reverse Phase High Performance Liquid Chromatographic Determination Of Zidovudine And Lamivudine In Tablet Dosage Form.
Palled MS, et al.
Indian Journal of Pharmaceutical Sciences, 67(1), 110-110 (2005)
Photoelectron spectra of important drug molecules: Zidovudine and Artemisinine
Novak I and Kovac B
The Journal of Organic Chemistry, 68(14), 5777-5779 (2003)
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