A143
(S)-(−)-Atenolol
powder
Sinónimos:
(−)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
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Fórmula lineal:
(CH3)2CHNHCH2CH(OH)CH2OC6H4CH2CONH2
Número CAS:
Peso molecular:
266.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Servicio técnico
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powder
optical activity
[α]23/D −10.5°, c = 0.5 in H2O(lit.)
color
white to beige
mp
148-152 °C (lit.)
solubility
0.1 M HCl: soluble
SMILES string
CC(C)NC[C@H](O)COc1ccc(CC(N)=O)cc1
InChI
1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m0/s1
InChI key
METKIMKYRPQLGS-LBPRGKRZSA-N
Gene Information
human ... ADRB1(153)
Application
(S)-(-)-Atenolol may be used as a standard in the preparation of enantiomer for high-performance liquid chromatography-tandem mass spectrometry studies (HPLC-MS/MS). It has also been used in the β blocking molecule for Raman spectroscopy studies.
Biochem/physiol Actions
(S)-(-)-Atenolol is a β1-adrenergic receptor antagonist and an active enantiomer of atenolol.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The Journal of pharmacology and experimental therapeutics, 250(3), 759-763 (1989-09-01)
Previous studies have demonstrated that propranolol can lower arterial pressure through an action within the central nervous system. The purpose of this study was to determine 1) whether the hydrophilic beta blocking drug atenolol which is devoid of membrane stabilizing