A4941
Activin A human
≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
Sinónimos:
Activin A Protein, Growth Factor, Human Growth Factor
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Biological source:
human
Recombinant:
expressed in baculovirus infected insect cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 26 kDa (containing 116 amino acid residues βA subunits)
Impurities:
endotoxin, tested
Servicio técnico
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Permítanos ayudarleNombre del producto
Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
biological source
human
Quality Level
recombinant
expressed in baculovirus infected insect cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
1-10 ng/mL ED50
mol wt
dimer 26 kDa (containing 116 amino acid residues βA subunits)
packaging
pkg of 10 μg, pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... INHBA(3624)
General description
Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.
Application
Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.
Biochem/physiol Actions
Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).
Physical form
Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.
Analysis Note
The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenido relacionado
Instructions
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)