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C9538

Coenzyme Q10

≥98% (HPLC), powder, antioxidant

Sinónimos:

CoQ10, Q-10, Ubiquinone 50, Ubiquinone-10

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Fórmula empírica (notación de Hill):
C59H90O4
Número CAS:
303-98-0
Peso molecular:
863.34
NACRES:
NA.77
PubChem Substance ID:
24893170
UNSPSC Code:
12352200
EC Number:
206-147-9
MDL number:
MFCD00042919
Beilstein/REAXYS Number:
1900141
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200
Servicio técnico
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Nombre del producto

Coenzyme Q10, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

yellow to dark orange

mp

49 °C

application(s)

cell analysis

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

General description

Coenzyme Q (CoQ), also known as ubiquinone, is a lipid-soluble antioxidant and is an essential component of the mitochondrial electron transport chain. The molecule contains a biologically active quinone with a benzoquinone ring and an isoprenoid sidechain. Q10 is synthesized in the cytoplasm and mitochondria () which generates ATP through aerobic cellular respiration. CoQ10 is required for the optimal functioning of the immune system and for cardiovascular health (). The ability to repress inflammatory gene expression exhibits its anti-inflammatory property ( ) Genetic failure or ageing results in CoQ10 deficiency, indicated by suppression of immune function. ()

Application

Coenzyme Q10 (CoQ10) has been used:
  • as a bioactive compound to study its immune modulating properties in vitro
  • as a standard for high-performance liquid chromatography
  • to study its effect on exercised rat aorta
  • in the cellular CoQ uptake assay

Biochem/physiol Actions

Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000544105
0000544054
0000544055
0000539742
0000538792

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Lionel Van Maldergem et al.
Annals of neurology, 52(6), 750-754 (2002-11-26)
A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical and biochemical abnormalities improved remarkably
Steven Lunetta et al.
Journal of AOAC International, 91(4), 702-708 (2008-08-30)
An international collaborative study was conducted of a high-performance liquid chromatographic (HPLC)-UV method for the determination of coenzyme Q10 (CoQ10, ubidecarenone) in raw materials and dietary supplements. Ten collaborating laboratories determined the total CoQ10 content in 8 blind duplicate samples.
Jan Aaseth et al.
Mechanisms of ageing and development, 197, 111521-111521 (2021-06-16)
Coenzyme Q10 (CoQ10) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ10 by a specialized cytoplasmatic-mitochondrial pathway. CoQ10 deficiency can result from genetic failure or
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