D0390
NG,NG′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt
≥99% (TLC)
Sinónimos:
SDMA
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Fórmula empírica (notación de Hill):
C8H18N4O2 · 2C12H10N2O4S
Número CAS:
Peso molecular:
758.82
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Level
assay
≥99% (TLC)
form
powder
solubility
methanol: 10 mg/mL
storage temp.
room temp
SMILES string
CN\C(NC)=N\CCC[C@H](N)C(O)=O.Oc1ccc(cc1)\N=N\c2ccc(cc2)S(O)(=O)=O.Oc3ccc(cc3)\N=N\c4ccc(cc4)S(O)(=O)=O
InChI
1S/2C12H10N2O4S.C8H18N4O2/c2*15-11-5-1-9(2-6-11)13-14-10-3-7-12(8-4-10)19(16,17)18;1-10-8(11-2)12-5-3-4-6(9)7(13)14/h2*1-8,15H,(H,16,17,18);6H,3-5,9H2,1-2H3,(H,13,14)(H2,10,11,12)/b2*14-13+;/t;;6-/m..0/s1
InChI key
HISUXCNNXYEHER-YJSASASGSA-N
Application
Plasma sym-dimethylarginine has been considered a marker of hepatic and renal dysfunction. A sensitive LC-MS method for identifying arginine, and both asym- and sym-dimethylarginine in plasma and urine samples has been developed.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Lena Pelander et al.
Journal of veterinary internal medicine, 33(2), 630-639 (2019-02-23)
Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required. To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection
Jane Yu et al.
Animals : an open access journal from MDPI, 10(6) (2020-06-12)
The pharmacokinetic profile of mefloquine was investigated as a preliminary study towards a potential treatment for feline coronavirus infections (such as feline infectious peritonitis) or feline calicivirus infections. Mefloquine was administered at 62.5 mg orally to seven clinically healthy cats
Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma.
Shahrbanou Javadiyan et al.
Investigative ophthalmology & visual science, 53(4), 1923-1927 (2012-03-08)
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are the dimethylated isomeric derivatives of the amino acid L-arginine. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS), while SDMA is a competitive inhibitor of cellular uptake of L-arginine, the substrate