D3630
Diphenhydramine hydrochloride
≥98% (HPLC), H1 histamine receptor antagonist, powder
Sinónimos:
2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
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Fórmula empírica (notación de Hill):
C17H21NO · HCl
Número CAS:
Peso molecular:
291.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
205-687-2
MDL number:
Servicio técnico
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Permítanos ayudarleNombre del producto
Diphenhydramine hydrochloride, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
originator
Johnson & Johnson
SMILES string
Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
InChI
1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
InChI key
PCHPORCSPXIHLZ-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
Application
Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies
Biochem/physiol Actions
H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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R U Agu et al.
Pharmaceutical research, 16(9), 1380-1385 (1999-09-25)
To test two in vitro human nasal epithelial cell culture systems for their ability to screen the effects of pharmaceutical compounds on ciliary beating. Human nasal epithelial cells were cultured as monolayer and in a sequential monolayer-suspension culture with in
Clinical evaluation of diphenhydramine hydrochloride for the treatment of insomnia in psychiatric patients: a double-blind study
Kudo Y and Kurihara M
Journal of Clinical Pharmacology, 30(11), 1041-1048 (1990)
Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection
Matty MA, et al.
eLife, 8, e39123-e39123 (2019)