F3388
Ferric citrate
BioReagent, suitable for cell culture
Sinónimos:
Iron(III) citrate, Iron(III) citrate hydrate
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Fórmula empírica (notación de Hill):
C6H5FeO7
Número CAS:
Peso molecular:
244.94
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352205
EC Number:
222-536-6
MDL number:
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Level
product line
BioReagent
technique(s)
cell culture | mammalian: suitable
solubility
hot water: 0.01 g/mL, clear, orange-yellow
shipped in
ambient
storage temp.
room temp
SMILES string
OC12CC(=O)O[Fe](OC(=O)C1)OC2=O
InChI
1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
InChI key
NPFOYSMITVOQOS-UHFFFAOYSA-K
Application
Ferric citrate provides a source of iron used in cell culture applications. It provides iron in a less toxic form than free iron salts. Ferric citrate has been used as medium supplement in human osteosarcoma cell (U2OS) culture, human embryonic kidney (HEK293) cells and adult primary cardiomyocytes.
Biochem/physiol Actions
Ferric citrate is used as a component of protein-free medium. It is used as a substitute for transferrin in mouse hybridomas culture. Ferric citrate enhances IgM production. It indirectly stimulates the mitogen-activated protein kinase (MAPK) by favoring high amphiregulin oncoprotein levels in colon cancer. Ferric citrate is effective in binding to phosphate in patients with dialysis-dependent chronic kidney disease.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenido relacionado
Development of a protein-free medium with iron salts replacing transferrin for a human-human hybridoma
Nagira K, et al.
Bioscience, Biotechnology, and Biochemistry, 59(4), 743-745 (1995)
Nonantibiotic effects of fluoroquinolones in mammalian cells
Badal S, et al.
The Journal of Biological Chemistry, 290(36), 22287-22297 (2015)
Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells
Scheers NM, et al.
Oncotarget, 9(24), 17066-17066 (2018)