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I0516

Insulin solution from bovine pancreas

Name: Insulin solution from bovine pancreas
Brand: SIGMA

BioReagent, 10 mg/mL insulin in 25 mM HEPES, pH 8.2, sterile-filtered, suitable for cell culture

Sinónimos:

Bovine insulin, Cell culture grade insulin

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Número CAS:

11070-73-8

UNSPSC Code:

12352209

NACRES:

NA.77

MDL number:

MFCD00131380

Biological source:

bovine

Form:

solution

Servicio técnico

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Propiedades

biological source

bovine

Quality Segment

400

sterility

sterile-filtered

product line

BioReagent

form

solution

concentration

10 mg/mL insulin in 25 mM HEPES, pH 8.2

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

impurities

endotoxin, tested

pH

7.9-8.5

UniProt accession no.

P01317

shipped in

ambient

storage temp.

2-8°C

SMILES string

SC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@H](CC)C)C(C)C)CCC(=O)O)CCC(=O)N)CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4ccc(cc4)O)C(=O)N[

InChI

1S/2C97H151N25O34S4/c2*1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h2*13-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1

InChI key

XYPANFGXFLOTDK-CJLNJPJHSA-N

Gene Information

bovine ... INS(280829)
cow ... INS(280829)

Descripción

Application

Insulin solution from bovine pancreas has been used:

to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth factor I (IGF-I), and progesterone (P4) in pubertal beef heifers
to study the insulin responsiveness of the placenta during pregnancy complications using primary human trophoblast cells and placental villous explants
to study the effect of insulin receptor signaling dendritic spine density in neonatal mouse hippocampal neurons in vitro

Biochem/physiol Actions

Insulin is a major glucose-lowering hormone, insufficiency of which causes hyperglycemia observed in type 2 diabetes.

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Physical form

stable 2-8 °C

Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

ppe

Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number

0000446369

0000354948