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K1751

Ketoprofen

Name: Ketoprofen
Brand: SIGMA

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

Sinónimos:

2-(3-Benzoylphenyl)propionic acid

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Fórmula empírica (notación de Hill):

C₁₆H₁₄O₃

Número CAS:

22071-15-4

Peso molecular:

254.28

NACRES:

NA.77

PubChem Substance ID:

57654315

UNSPSC Code:

12352200

EC Number:

244-759-8

MDL number:

MFCD00055790

Assay:

≥98% (TLC)

Form:

powder

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Propiedades

Nombre del producto

Ketoprofen, ≥98% (TLC)

biological source

synthetic

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to yellow

originator

Bayer

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

Gene Information

human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)

Descripción

General description

Ketoprofen belongs to the class of 2-arylpropionic acid.

Application

Ketoprofen has been used:

as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Biochem/physiol Actions

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H315,H319,H400

pcodes

P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c