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LO1280

LOPAC®1280

liquid

Sinónimos:

Library of Pharmacologically Active Compounds

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UNSPSC Code:
12352202
Form:
liquid
Quality level:
100
Servicio técnico
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Nombre del producto

LOPAC®1280,

form

liquid

Quality Level

100

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

shipped in

dry ice

storage temp.

−20°C

General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO).

Application

LOPAC®1280 has been used:
  • in the screening of novel inhibitors for chemotaxis/ migration using Dictyostelium as a model
  • to test the ability to modulate and to measure forskolin-stimulated cAMP levels in CHO-hCB2 cells and to modulate ligand-induced receptor/β-arrestin interaction
  • in screening of small molecules for activating bone morphogenetic protein (BMP) signaling
  • in screening of compounds that plays a role in regulating subcellular localization of nitric oxide associated protein 1 (NOA1) protein

Features and Benefits

Collection of 1,280 Pharmacologically-Active Sigma Compounds
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position
To request a list of components, please visit sigma.com/LOPAC

Other Notes

For sale in the U.S. only. Customers outside of the U.S. should refer to product code LO3300.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
0000234627
0000234627
0000134765
0000130856
0000089753

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A Unique High-Throughput Assay to Identify Novel Small Molecule Inhibitors of Chemotaxis and Migration
Liao XH and Kimmel AR
Current Protocols in Cell Biology, 74(1), 12-11 (2017)
Karen Camargo-Sosa et al.
PLoS genetics, 15(2), e1007941-e1007941 (2019-02-28)
Skin pigment patterns are important, being under strong selection for multiple roles including camouflage and UV protection. Pigment cells underlying these patterns form from adult pigment stem cells (APSCs). In zebrafish, APSCs derive from embryonic neural crest cells, but sit
Identification of small molecule activators of BMP signaling
Vrijens K, et al.
PLoS ONE, 8(3), e59045-e59045 (2013)
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