N0258
N-Nitrosodiethylamine
ISOPAC®
Sinónimos:
Diethylnitrosamine
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Fórmula lineal:
(C2H5)2NNO
Número CAS:
Peso molecular:
102.14
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-226-1
Beilstein/REAXYS Number:
1744991
MDL number:
Form:
liquid
Quality level:
Servicio técnico
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Permítanos ayudarleQuality Level
form
liquid
bp
177 °C (lit.)
density
0.95 g/mL (lit.)
SMILES string
CCN(CC)N=O
InChI
1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
InChI key
WBNQDOYYEUMPFS-UHFFFAOYSA-N
Application
N-Nitrosodiethylamine (NDEA) has been used as a hepatocarcinogen/DNA damaging agent. It has been used as a calibration standard for gas–liquid chromatography.
Biochem/physiol Actions
N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. It is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. NDEA is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. It results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
Packaging
Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
Preparation Note
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Injecting any compatible solvent permits preparation of any desired strength solution without exposure.
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Singh BN
Chemico-Biological Interactions, 181, 20-20 (2009)
Yewei Liu et al.
International journal of cancer, 143(7), 1817-1828 (2018-05-01)
To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation
Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice.
Pracheta P
Asian Pacific Journal of Cancer Prevention, 12, 677-677 (2011)