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R9644

Ribavirin

Name: Ribavirin
Brand: SIGMA

≥98% (TLC), IMP dehydrogenase inhibitor, powder

Sinónimos:

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

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Fórmula empírica (notación de Hill):

C₈H₁₂N₄O₅

Número CAS:

36791-04-5

Peso molecular:

244.20

UNSPSC Code:

12352202

PubChem Substance ID:

24278685

NACRES:

NA.77

MDL number:

MFCD00058564

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Propiedades

Nombre del producto

Ribavirin, antiviral

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

InChI key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

Descripción

General description

Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Chemical structure: nucleoside

Biochem/physiol Actions

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.

Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.

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pictograms

GHS08

signalword

Danger

hcodes

H341,H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c