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SML0061

SAHA

Name: SAHA
Brand: SIGMA

≥98% (HPLC), powder, HDAC inhibitor

Sinónimos:

N-hydroxy-N′-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat

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Fórmula empírica (notación de Hill):

C₁₄H₂₀N₂O₃

Número CAS:

149647-78-9

Peso molecular:

264.32

UNSPSC Code:

12352200

PubChem Substance ID:

329825127

NACRES:

NA.77

MDL number:

MFCD00945317

Assay:

≥98% (HPLC)

Form:

powder

Servicio técnico

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Propiedades

Nombre del producto

SAHA, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

ONC(=O)CCCCCCC(=O)Nc1ccccc1

InChI

1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

InChI key

WAEXFXRVDQXREF-UHFFFAOYSA-N

Gene Information

human ... HDAC1(3065), HDAC2(3066), HDAC3(8841), HDAC6(10013)

Descripción

Application

SAHA may be used to study gene regulation, transcription regulation and cell signaling.

Biochem/physiol Actions

Potent, reversible pan-histone deacetylase (HDAC) inhibitor.

Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs, altering gene transcription and inducing cell cycle arrest and/or apoptosis in a wide variety of transformed cells.

SAHA or Vorinostat facilitates the transcription of genes that result in apoptosis, differentiation and growth arrest. It has been observed to give beneficial results in lymphoma but not in solid tumors.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

GHS08

Palabra de advertencia

Danger

Códigos de peligro

H341,H360

Indicaciones de precaución

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)